Recombinant Human IL-18BP (IL-18 Binding Protein)
Interleukin-18 binding protein (IL-18BP) is a secreted glycoprotein recognized for its pivotal role in immune regulation. By binding to the proinflammatory cytokine IL-18, IL-18BP effectively inhibits its activity, thus modulating T-helper type 1 immune responses. Notably, IL-18BP lacks a transmembrane domain and exhibits constitutive expression across various tissues. Its heightened presence in the intestinal tissues of individuals with Crohn's disease underscores its potential significance in inflammatory conditions.
Sequence:
MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVA
CSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPP
TQEALPSSHSSPQQQG with polyhistidine tag at the C-terminus
UnitProt ID:
O95998
Source:
HEK293
Endotoxin Test:
<0.1 EU per 1 μg of the protein by the LAL method.
Purity:
>95% as determined by SDS-PAGE.
Form:
Lyophilized
Storage Buffer:
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution:
It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Stability & Storage:
This product is stable after storage at:
• -20°C for 12 months in lyophilized state from date of receipt.
• -20°C or -80°C for 1 months under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
Shipping Conditions:
Blue ice
MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVA
CSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPP
TQEALPSSHSSPQQQG with polyhistidine tag at the C-terminus
UnitProt ID:
O95998
Source:
HEK293
Endotoxin Test:
<0.1 EU per 1 μg of the protein by the LAL method.
Purity:
>95% as determined by SDS-PAGE.
Form:
Lyophilized
Storage Buffer:
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution:
It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Stability & Storage:
This product is stable after storage at:
• -20°C for 12 months in lyophilized state from date of receipt.
• -20°C or -80°C for 1 months under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
Shipping Conditions:
Blue ice